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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COPS6 All Species: 25.45
Human Site: Y280 Identified Species: 56
UniProt: Q7L5N1 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7L5N1 NP_006824.2 327 36163 Y280 D K F K T D F Y D Q C N D V G
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001100125 326 36044 Y279 D K F K T D F Y D Q C N D V G
Dog Lupus familis XP_536866 321 35704 Y274 D K F K T D F Y D Q C N D V G
Cat Felis silvestris
Mouse Mus musculus O88545 324 35862 Y277 D K F K T D F Y D Q C N D V G
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q6NUC2 318 35518 Y271 D K F K T D F Y D Q C N D V G
Zebra Danio Brachydanio rerio NP_001017768 297 33615 G257 Y D Q C N D V G L M A Y L G T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VCY3 341 38287 Y294 P A F Q E E F Y T Q C N D V G
Honey Bee Apis mellifera XP_393678 338 37998 Y291 P K F K A D F Y N Q C N D F G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001192086 297 33638 T257 Y N Q C N D V T L M A Y L G A
Poplar Tree Populus trichocarpa XP_002330530 306 34249 N264 D D F L M E Y N D T L L I A Y
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8W206 317 35640 L271 E R F Q D N F L M E Y N D K L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99 97.5 N.A. 97.8 N.A. N.A. N.A. N.A. 88.6 83.7 N.A. 56.8 62.7 N.A. 70
Protein Similarity: 100 N.A. 99 97.8 N.A. 98.4 N.A. N.A. N.A. N.A. 93.8 87.7 N.A. 75 76.3 N.A. 80.7
P-Site Identity: 100 N.A. 100 100 N.A. 100 N.A. N.A. N.A. N.A. 100 6.6 N.A. 60 73.3 N.A. 6.6
P-Site Similarity: 100 N.A. 100 100 N.A. 100 N.A. N.A. N.A. N.A. 100 6.6 N.A. 73.3 80 N.A. 6.6
Percent
Protein Identity: 35.4 N.A. N.A. 34.5 N.A. N.A.
Protein Similarity: 56.8 N.A. N.A. 56.5 N.A. N.A.
P-Site Identity: 20 N.A. N.A. 26.6 N.A. N.A.
P-Site Similarity: 33.3 N.A. N.A. 60 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 10 0 0 0 0 0 19 0 0 10 10 % A
% Cys: 0 0 0 19 0 0 0 0 0 0 64 0 0 0 0 % C
% Asp: 55 19 0 0 10 73 0 0 55 0 0 0 73 0 0 % D
% Glu: 10 0 0 0 10 19 0 0 0 10 0 0 0 0 0 % E
% Phe: 0 0 82 0 0 0 73 0 0 0 0 0 0 10 0 % F
% Gly: 0 0 0 0 0 0 0 10 0 0 0 0 0 19 64 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 0 55 0 55 0 0 0 0 0 0 0 0 0 10 0 % K
% Leu: 0 0 0 10 0 0 0 10 19 0 10 10 19 0 10 % L
% Met: 0 0 0 0 10 0 0 0 10 19 0 0 0 0 0 % M
% Asn: 0 10 0 0 19 10 0 10 10 0 0 73 0 0 0 % N
% Pro: 19 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 19 19 0 0 0 0 0 64 0 0 0 0 0 % Q
% Arg: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 46 0 0 10 10 10 0 0 0 0 10 % T
% Val: 0 0 0 0 0 0 19 0 0 0 0 0 0 55 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 19 0 0 0 0 0 10 64 0 0 10 19 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _